Wireless communications is a rapidly growing piece of the communications manufacturing, with the potential to provide high-speed high-quality information exchange between the portable devices located anywhere in the world. Multi-Carrier Code Division Multiple Access (MC-CDMA) has emerged recently as a promising candidate for the next generation broad-band mobile networks. Recently, it was found that Slantlet transform (SLT) based Orthogonal Frequency Division Multiplexing (OFDM) is capable to reduce the Inter Symbol Interference (ISI) and the Inter Carrier Interference (ICI), which are caused by the loss of orthogonality between the sub-carriers. SLT-OFDM can support higher spectrum efficiency than Fast Fourier Transform-based OFDM (FFT-OFDM) due to the elimination of the Cyclic Prefix (CP). In this paper, a novel SLT-MC-CDMA transceiver design is presented based on the SLT-OFDM that is used as a basic building block in the design of MC-CDMA transceiver to maintain the orthogonality against the multi-path frequency Selective Fading Channels (SFC). Simulation results are provided to demonstrate the significant gain in the performance of the proposed technique. The Bit Error Rate (BER) of SLT-MC-CDMA scheme is compared with FFT-MC-CDMA and tested in Additive White Gaussian Noise (AWGN), Flat Fading and Selective Fading Channels (SFH). The simulation results confirmed that, the proposed system outperforms the reference one.