Nowadays, big data is directing the entire advanced world with its function and applications. Moreover, to make better decisions from the ever emerging big data belonging to the respective organizations, deep learning (DL) models are required. DL is also widely used in the sentiment classification tasks considering data from social networks. Furthermore, sentiment classification signifies the best way to analyze the big data and make decisions accordingly. Analyzing the sentiments from big data applications is quite challenging task and also requires more time for the execution process. Therefore, to analyze and classify big data emerging from social networks in a better way, DL models are utilized. DL techniques are being used among the researchers to get high end results. A novel Ant Colony-based Deep Belief Neural Network (AC-DBN) framework is proposed in this research. Drug review tweets are opted to perform sentiment classification by using the proposed framework in python environment. A model fitness function is initiated in the DL framework and is observed that it is attaining high accuracy with low computation time. Additionally, the obtained results attained from the proposed framework are validated with existing methods for evaluating the efficiency of the proposed AC-DBN approach.