“Data Structure” is the core of computer science courses, which is closely related to “Programming Language”, “Discrete Mathematics”, “Operating System” and “Compiler Principle”. The five courses have a strong relationship between academic edge in the teaching content, teaching model and teaching method. This paper proposes a method of overall optimization based on a series of data structure courses teaching content. The method explains inherent relationships among the courses so as to avoid to be disconnected each other. As a result, general efficiency of the five courses teaching is increased and the students’ ability of the data abstraction and algorithm design is improved.