Audio communications in IP based networks have been revolutionized by the introduction of VoIP applications. High cost-efficiency has made VoIP to be the communication means in today’s world; and this trend is anticipated to be continued on an ongoing basis. The performance of VoIP significantly depends on the efficiency of the audio codecs used in any communication scenario which make the study on the performance issues of audio codecs in VoIP applications worth investigating. IPv6 is the new version of IP, which will gradually replace the current IPv4 as the transition from IPv4 to IPv6 is already in place. This demands the scrutiny of the audio codecs being used in IPv4 to be tested for their compatibility in IPv6 in terms of desired performance. This paper presents the study on the performance of selected audio codecs that are widely used in VoIPv4. G.711, G.729A and G.723.1 codecs were chosen for the study in VoIPv6 based scenarios presented in this paper. The selected audio codecs were applied in IPv6 based voice communication network scenarios to determine their performance efficiency by observing various QoS parameters. The study was done by means of simulation using OPNET.