Online interactions provide a large knowledge exchange on variety kinds of information exchanged between users. There are many software systems available that provide online learning systems, this type of software expressed by forms, commercial or open source software. This paper is focused on Moodle, it explained the comparative study that done by many recent researches, it also shows the different between Moodle and other learning management systems, in order to discover their strengths and limitations, discusses different points in these systems. Moodle has been adopted by many universities and organizations the entire world because it offers a large accusable set of tools, and many components was developed without a specific design documentation including its security services. This paper shows the comparative study between Moodle and other e-learning systems; it aimed to discover the best and most suitable choice of e-learning system. We have fined the optimal e-learning platform required to our e-learning university system, and it is Moodle, according to the used by many Universities around the word and from many works that has been done to date that encourages the used and develops this type of LMS.