Nowadays college students’ studying-weariness is a common problem needs to be solved in China. Also, college students' studying-interest, studying-weariness psychology and misbehaviors have been the subject of considerable research in the last few years to educators and researchers all over the world. However, most of the existing studies in this field are qualitative theory analysis and short of actual investigation, survey and even less mathematical quantificational study. The investigation and study on studying-interest of college students from four universities in Wuhan demonstrates that college students show generally studying-weary mentality and correlative misbehaviors. With the designed college students' learning-interest questionnaire, college students in four universities of Wuhan were surveyed. And based on this survey, Structural Equation Model (SEM) was used to analyze the date of our investigation of the factors affecting college students’ studying-interest and studying-weariness. Results of our quantitative statistical analysis with mathematical model show the degree of each factor influencing studying-interest and studying-weariness. School-related factor and society-related factor are the main influences on college students’ studying-interest and studying-weariness. The major objective of this paper is to provide an integrative review of the college students’ studying-interest and studying-weariness, in order to contribute to the development of high education. Countermeasures and Suggestions are also put forward to rectify the college students’ studying-weariness. This work will play an important role for education departments and educators to take corresponding measures to provide scientific guidance of high education.