Coronary artery disease (CAD) causes millions of deaths worldwide every year. The earliest possible diagnosis is quite important, as in any diseases, for heart diseases causing such a large amount of death. The diagnosis processes have been more successful thanks to the recent studies in medicine and the rapid improvement in computer sciences. In this study, the goal is to employ machine learning methods to facilitate rapid disease diagnosis without the need to observe negative outcomes. The dataset utilized in this study was obtained from an IEEE DataPort data repository. The dataset consists of two classes. Firstly, new features have been produced by using the features in the dataset. Then, datasets that consist of multiple features have been created by using feature selection algorithms. Three models, specifically Support Vector Machines (SVM), the k-Nearest Neighbor algorithm (kNN), and Decision Tree ensembles (EDT), were trained using custom datasets. A hybrid model has been created and the performances have been compared with the other models by using these models. The best performance has been obtained from SVM and its seven performance criteria in order of accuracy, sensitivity, specificity, F- measurement, Kappa and AUC are 97.82, 0.97, 0.99, 0.98, 0.96 and 0.98%. In summary, when evaluating the performance of the constructed models, it has been demonstrated that these recommended models could aid in the swift prediction of coronary artery disease in everyday life.

Fibromyalgia is a chronic pain syndrome that generally appears with prevalent muscular pain, sleep disorder and fatigue. Its diagnosis is very difficult. It is diagnosed in a long time after evaluating variety of psychological test scores along with physiological and laboratory tests. Psychological tests are thought not to be as reliable as laboratory test results since they depend on oral reports of the patients, and can differ from patient to patient. Beck depression inventory is one of the psychological test scores. In this study, a new biological signal that could be used instead of Beck depression inventory is introduced. For this purpose, sympathetic skin responses were used along with physiological and laboratory test results that were collected both from diagnosed fibromyalgia patients and healthy patients. A relationship based on classification was aimed to be established between the data and Beck depression inventory by using artificial neural networks. Three different artificial neural network training algorithm were used in the study. According to the results, physiological and laboratory test results and back depression inventory were estimated with the accuracy rate of 77.70\%. When all the data were used with Levenberg-Marquardt back propagation training algorithm, this rate went up to 90.91\%. According to these results, sympathetic skin responses can be safely used instead of Beck depression inventory when they were used along with other parameters that were used in fibromyalgia diagnosis.

In this study; values obtained through the analysis of blood samples, taken under laboratory conditions, from patients diagnosed with fibromyalgia syndrome and healthy subjects and the sympathetic skin response parameters were used. With the aim of classifying verbal pain scale, which is one of the psychological test scores used for fibromyalgia syndrome diagnosis; relation between the sympathetic skin response effect on other test data and the verbal pain scale were reviewed by using different conditions of available data. Within this framework, three different algorithms were used for classification with high accuracy rates. These algorithms are: Multi-Layer Feed-Forward Neural Networks, Probabilistic Neural Network and Radial Basis Function Neural Network. For Multi-Layer Feed-Forward Neural Networks classification algorithm, classification was done with three different training algorithms, Levenberg-Marquardt back propagation, Resilient back propagation and the Scaled conjugate gradient back propagation and the results were compared elaborately. Based on the results, by using all variables the following accuracy rates were obtained: 68.2% accuracy with Levenberg-Marquardt training algorithm, 77.3% accuracy with the Resilient back propagation training algorithm, and 68.18% accuracy with the Scaled conjugate gradient training algorithm. These success rates show that there is a relationship between verbal pain scale, sympathetic skin response and other test data.