The quality of microscopic images is generally degraded during the image acquisition by quantizing noise, electrical noise, light illumination etc. Noise reduction is considered as a very important preprocessing step as the quality of the images can determine the accuracy of the results. The work done focuses on the noise reduction using different filters on the different types of noises applied on the common digital images and specifically the Leukemia images. 40 images were taken for the comparison purpose; 20 digital images and 20 Leukemia images of different types of Leukemia. The qualitative as well as quantitative analysis of the performance of the filters on the different noises is done. For the quantitative analysis the parameters used for the evaluation of the images are MSE, PSNR and CoC. For the qualitative analysis visual analysis in terms of quality is also done using the resultant images and their histograms. Simulation has been done in Matlab 11b. From the test cases it has been observed that Adaptive Filter produces good results on Salt and Pepper, Speckle and Gaussian noise in case of the digital images. Whereas in case of Leukemia images results of Median Filter are best for the Gaussian, Poisson and Speckle noise corrupted images.