In the world ergonomics is involved everywhere, where is work there is a risk factor. Musculoskeletal disorder (MSDs) is a major risk factor in human life because it affects bones, joints, muscles, and connective tissues of whole human body parts such as the neck, shoulder, arms, wrists, hips, legs, thigh, knee, ankles, etc. so mainly our study focus on musculoskeletal disorders. This study there has used questionnaires in four factors those are socio-demographic, psychological, occupational, and biomechanical. In these factors number of questions were included in the data has been collected. In addition, there was the Nordic section in questions from that we analyzed the pain in different parts of the human body. The study concentrated on the business, education, industry, and healthcare sectors in Hyderabad, Kotri, and Jamshoro. University students and teachers, retail salespeople, manufacturing industry workers, nurses, doctors, nursing assistants, and other health professionals comprised the sample group. The questionnaires were fully completed by 50% of the respondents, resulting in a sample of 116 workers. The majority of the participants were private employees with one to fifteen years of experience in teaching or caring. In this study data has been analyzed through Co-relation between four factors with the Nordic section and ANOVA test through excel and it gives the value of p is also less than 0.05 so we cannot reject the null hypothesis. Over this study it has been analyzed that population is evolving in problems and there should be the proper implementation of ergonomics and safety rules. Test gives the values are not significant and null hypothesis should not reject and it should be improving.