The digital transformation of the healthcare sector has revolutionized operational efficiency and patient care, yet concurrently exposed healthcare organizations to unprecedented cybersecurity risks, jeopardizing patient confidentiality and organizational integrity. This study undertakes a comprehensive investigation into contemporary cybersecurity strategies and emerging trends within the healthcare industry. Through a meticulous examination of published literature from reputable databases, including PubMed/MEDLINE, CINAHL, and Web of Science, critical patterns and vulnerabilities are discerned, underlining the escalating frequency and severity of cyber threats such as ransomware and phishing attacks. Emphasizing the pivotal role of organizational cyber resilience governance and policies, the study identifies a notable gap in standardized cybersecurity risk assessment methodologies, signaling the urgent need for innovative approaches. In response to identified challenges, the research proposes the development of novel methodologies to fortify cybersecurity defenses and protect patient data. Leveraging cutting-edge technologies such as blockchain and artificial intelligence, the study advocates for proactive measures to mitigate emerging threats and ensure data security and patient privacy in healthcare environments. Moreover, the integration of end-to-end security measures and the adoption of DevOps methodologies are highlighted as promising avenues for enhancing cybersecurity resilience. Results from a systematic literature review underscore the imperative for ongoing research and collaboration to address cybersecurity challenges in healthcare effectively. By offering insights into key cybersecurity features, technologies, and responsibilities within the healthcare sector, this study aims to inform stakeholders and policymakers, facilitating the implementation of robust cybersecurity measures. Furthermore, the study presents key findings regarding the current state of cybersecurity in healthcare, including challenges faced and potential solutions identified through the research process. Ultimately, through concerted efforts and the utilization of innovative strategies, healthcare organizations can navigate the evolving cybersecurity landscape, safeguarding patient information and upholding the integrity of healthcare systems.