The internet was basically designed for the static nodes, but with the development of mobile nodes such as smart phones, that have wireless capabilities, the first design was insufficient. MNs change their point of attachment while they are roaming (traveling) in the internet, to maintain the survival of ongoing sessions for these mobile nodes, the internet requires techniques for managing mobility.. Currently, there are two types of mobility management protocols, host-based protocols and network-based protocols, the involvement of MN in the mobility process is must in the first type, while is unnecessary in the second type. The IETF standardized the Proxy Mobile IPv6 (PMIPv6) protocol in 2004, to overcome the limitations experienced by the host-based protocol, Mobile IPv6 (MIPv6) such as sub-optimal routing, handover latency, packet loss and single point of failure, however, the biggest drawback of PMIPv6 is the lack of inter-domain handover. This paper provides an efficient scheme based on standard PMIPv6 called (E-PMIPv6) to support inter-domain handover by introducing a new entity called (GLMA) which enables MN to traverse different domains while keeping the ongoing sessions, additionally; we use buffering techniques to preemptively lighten packet losses. The ultimate goal for the suggested scheme is to solve the scalability problem for the PMIPv6 and it is extensions to encourage network operators to deploy E-PMIPv6 for large networks. Results of preliminary analysis of handover latencies and related packet losses favored (E-PMIPv6) over two of the leading contenders.