International Journal of Image, Graphics and Signal Processing (IJIGSP)
IJIGSP Vol. 3, No. 3, 8 Apr. 2011
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Capsaicin-induced Thermal Enhancement on Target Tissues in Hyperthermia
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Author(s)
Peng Zeng
1,*
Zhong-Shan Deng
2
Jing Liu
2
Index Terms
Thermal enhancement, thermogenesis, capsai-cin, tumor hyperthermia, TRPV1, thermoregulation
Abstract
Local thermal enhancement in target tissue is of great interest in tumor hyperthermia. In this study, we proposed a brand-new thermal enhancement protocol for tumor hyperthermia using heat generated from thermoge-nesis evoked by capsaicin, which can safely deliver a totally localized heating to target tissue. A healthy male volunteer was recruited, whose partial areas of the dorsum of hand and posterior aspect of forearm were smeared with 1% (w/w) capsaicin solution, to determine the increase of ther-mogenesis in human body. In addition, animal experiments on healthy Kunming (KM) mice (20-22g) were performed to test the feasibility and efficacy of capsaicin-induced thermal enhancement. These KM mice were first locally smeared with, subcutaneous or intraperitoneal injected of the same capsaicin solution, and then heated by near infrared laser. Preliminary experiments on the volunteer showed an effec-tive temperature increase in the skin area. Animal experi-ments indicated that distinct thermal enhancement in heat-ing effect, and that the thermal enhancement induced by intraperitoneal injection of capsaicin is more obvious than the other two ways. Thus capsaicin can be used as a poten-tial therapeutic adjuvant to locally enhance heating effects in target tissue during tumor hyperthermia.
Cite This Paper
Peng Zeng,Zhong-Shan Deng,Jing Liu,"Capsaicin-induced Thermal Enhancement on Target Tissues in Hyperthermia", IJIGSP, vol.3, no.3, pp.49-55, 2011. DOI: 10.5815/ijigsp.2011.03.07
Reference
[1]Z. S. Deng, J. Liu, and J. R. Zhang, “Conformal RF abla-tion to reduce ‘dead region’ with adjuvant injection of magnetic micro/nano particles: feasibility study,” Interna-tional Conference on Integration and Commercialization of Micro and Nano-systems, 2007.
[2]Y. G. Lv, and J. Liu, “Research advancement on magnetic micro/nano particles aimed for tumor target hyperthermia treatment,” Nanomater. Struct., vol. 41, pp. 24-28, 2004. (in Chinese)
[3]J. Liu, and Z. S. Deng, Physics of tumor hyperthermia, Beijing: Science, 2008. (in Chinese)
[4]A. Akagi, N. Sano, H. Uehara, T. Minami, H. Otsuka, and K. Izumi, “Non-carcinogenicity of capsaicinoids inB6C3F(1) mice,” Food Chem. Toxicol., vol. 36, pp. 1065-1071, 1998.
[5]L. G. Copping, The BioPesticide Manual, 2nd ed., British Crop Protection Council, 2001.
[6]R. J. Bloomer, R. E. Canale, and K. H. Fisher-Wellman, “The potential role of capsaicinoids in weight manage-ment,” Agro Food Ind. Hi-Tech, vol. 20, pp. 33–35, 2009.
[7]W. Johnson, “Final report on the safety assessment of cap-sicum annuum extract, capsicum annuum fruit extract, cap-sicum annuum resin, capsicum annuum fruit powder, cap-sicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin,” Int. J. Toxicol, col.26, pp. 3–106, 2007.
[8]H. Knotkova, M. Pappagallo, and A. Szallasi, “Capsaicin (TRPV1 agonist) therapy for pain relief – Farewell or revi-al?” Clin. J. Pain, vol. 24, pp 142–154, 2008.
[9]A. Mori, S. Lehmann, J. O’kelly, et al., “Capsaicin, a com-ponent of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells,” Cancer Res., vol. 66, pp. 3222–3229, 2006.
[10]A. Jancsoga, J. Szolcsan, and N. Jancsó, “Irreversible im-pairment of thermoregulation induced by capsaicin and similar pugent substances in rats and guinea-pigs,” J. Phy-siol., vol. 206, pp 495–507, 1970.
[11]D. Turini, P. Beneforti, M. Spinelli, S. Malagutti, and M. Lazzeri, “Heat/burning sensation induced by topical appli-cation of capsaicin on perineal cutanesous area: New ap-proach in diagnosis and treatment of chronic prostati-tis/chronic pelvic pain syndrome?” Urology, vol. 67, pp. 910–913, 2006.
[12]M. J. Caterina, “Transient receptor potential ion channels as participants in thermosensation and thermoregulation,” Am. J. Physiol.-Regul. Integr. Comp. Physiol., vol. 292, pp. R64-R76, 2007.
[13]A. A. Romannosky, M. C. Almeida, A Garami, A. A. Steiner, M. H. Norman, S. F. Morrison, K. Nakamura, J. J. Burmeister, and T. B. Nucci, “The transient receptor poten-tial vanilloid-1 channel in thermoregulation: a thermosen-sor it is not,” Pharmacol. Rev., vol. 61, pp. 228-261, 2009.
[14]M. J. Caterina, M. A. Schumacher, M. Tominaga, T. A. Rosen, J. D. Levine, and D. Julius, “The capsaicin receptor: a heat-activated ion channel in the pain pathway,” Nature, vol. 398, pp. 816-824, 1997.
[15]M. J. Caterina, A. Leffler, A. B. Malmberg, W. J. Martin, J. Trafton, K. R. Petersen-Zeitz, M. Koltzenburg, A. I. Bas-baum, and D. Julius, “Impaired nociception and pain sen-sation in mice lacking the capsaicin receptor,” Science, vol. 288, pp. 306-313, 2000.
[16]Y. A. Mahmmoud, “Capsaicin stimulates uncoupled ATP hydrolysis by the sarcoplasmic reticulum calcium pump,” J. Biol. Chem., vol. 283, pp. 21418–21426, 2008.
[17]N. Jancsó, A. Jancsoga., and J. Szolcasn, “Direct evidence for neurogenic inlammation and its prevention by denerva-tion and by pretreatment with capsaicin,” Brit. J. Pharma-col. Chemother., vol. 31, pp. 138–151, 1967.
[18]C. A. Maggi, and A. Meli. “Suitability of urethane anesthe-sia for physiopharmacological investigations in various systems. 1. General-considerations,” Experientia, vol. 42, pp. 109-115, 1986.
[19]J. Speakman, and S. Ward, “Infrared thermograph: prin-ciples and applications,” 5th International Congress of Ver-tebrate Morphology – Noninvasive Imaging, Bristol Eng-land Gustav Fischer Verlag, pp. 224–232, 1998.
[20]G. H. Chen, W. J. Wang, L. Q. Zhang, and J. N. Zhou, “Age- and Sex-related disturbance in a battery of sensori-motor and cognitive tasks in Kunming mice,” Physiol. Be-hav., vol. 83,pp. 531-541, 2004.
[21]G.W. Guo, and X. Wang, Colour Atlas of Human anatomy, Beijing: Renmin Health, 2008. (in Chinese)
[22]J. F. Sanchez, J E. Krause, and D. N. Cotright, “The distri-bution and regulation of vanilloid receptor VR1 and VR1 5’ splice variant RNA expression in rat,” Neuroscience, vol. 107, pp. 373-381, 2001.
[23]S. Bevan, and J. Szolcsanyi, “Sensory neuron-specific actions of capsaicin: mechanisms and applications,” Trends in Pharmacol. Sci., vol. 11, pp. 330-333, 1990.